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Gao, Yang
BMC women's health, 05/2023, Volume: 23, Issue: 1Journal Article
Ovarian clear cell carcinoma (OCCC) is a unique subtype of ovarian epithelial ovarian cancer. The number of chemotherapy cycles for early-stage patients is still debated. This study aimed to evaluate whether at least 4 cycles of adjuvant platinum-based chemotherapy have better prognostic value than 1-3 cycles in early-stage OCCC. We retrospectively retrieved data from 102 patients with stage I-IIA OCCC between 2008 and 2017. All patients underwent complete surgical staging followed by adjuvant platinum-based chemotherapy. Kaplan-Meier curves and Multivariate Cox analysis were performed to estimate 5-year overall survival (OS) and progression-free (PFS) according to the number of chemotherapy cycles. Among stage I-IIA disease, twenty (19.6%) patients received 1-3 cycles, and eighty-two (80.4%) patients received at least 4 cycles of adjuvant chemotherapy. Univariate analysis revealed that the patients in 1-3cycles group had not significantly improved 5-year OS and PFS than those in the ≥ 4 cycles group (5-year OS: hazard ratio HR 1.21; 95% confidence interval CI 0.25- 5.78, p = 0.1), and 5-year PFS: HR 0.79; 95% CI 0.26- 2.34, p = 0.1). In the multivariate analysis, there was no impact of 1-3 versus ≥ 4 cycles of chemotherapy on 5-year OS (HR 1.21, 95% CI 0.25-3.89, p = 0.8) or 5-year PFS (HR 0.94, 95% CI 0.32-2.71, p = 0.9). The potential independent risk factors associated with 5-year OS and PFS included the surgery approach and FIGO stage. The number of cycles of platinum-based chemotherapy could not be associated with a survival benefit for patients with early-stage OCCC.
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