E-resources
Peer reviewed
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Bubnova, Alexandra S; Vorobyeva, Daria V; Godovikov, Ivan A; Smol’yakov, Alexander F; Osipov, Sergey N
Molecules (Basel, Switzerland), 11/2023, Volume: 28, Issue: 23Journal Article
An efficient method of accessing new CFsub.3-containing spiro-indene-proline derivatives has been developed based on a Cp*Rh(III)-catalyzed tandem C-H activation/3+2–annulation reaction of 5-aryl-2-(trifluoromethyl)-3,4-dihydro-2H-pyrrole-2-carboxylates with alkynes. An important feature of this spiro annulation process is the feasibility of dehydroproline moiety to act as a directing group in the selective activation of the aromatic C-H bond.
![Synthesis of CF[sub.3]-Cont...](http://api.summon.serialssolutions.com/2.0.0/image/issn/XR4PS5YY4K/1420-3049/medium "Synthesis of CF[sub.3]-Containing Spiro-[Indene-Proline] Derivatives via Rh-Catalyzed C-H Activation/Annulation")
