Abstract Collisions and interactions between gas-rich galaxies are thought to be pivotal stages in their formation and evolution, causing the rapid production of new stars, and possibly serving as a mechanism for fueling supermassive black holes (BHs). Harnessing the exquisite spatial resolution (∼0${^{\prime\prime}_{.}}$5) afforded by the first ∼170 deg2 of the Hyper Suprime-Cam (HSC) survey, we present our new constraints on the importance of galaxy–galaxy major mergers (1 : 4) in growing BHs throughout the last ∼8 Gyr. Utilizing mid-infrared observations in the WISE all-sky survey, we robustly select active galactic nuclei (AGN) and mass-matched control galaxy samples, totaling ∼140000 spectroscopically confirmed systems at i < 22 mag. We identify galaxy interaction signatures using a novel machine-learning random forest decision tree technique allowing us to select statistically significant samples of major mergers, minor mergers / irregular systems, and non-interacting galaxies. We use these samples to show that galaxies undergoing mergers are a factor of ∼2–7 more likely to contain luminous obscured AGN than non-interacting galaxies, and this is independent of both stellar mass and redshift to z < 0.9. Furthermore, based on our comparison of AGN fractions in mass-matched samples, we determine that the most luminous AGN population (LAGN ≳ 1045 erg s−1) systematically reside in merging systems over non-interacting galaxies. Our findings show that galaxy–galaxy interactions do, on average, trigger luminous AGN activity substantially more often than in secularly evolving non-interacting galaxies, and we further suggest that the BH growth rate may be closely tied to the dynamical time of the merger system.