Phenotypic differentiation does not affect tumorigenicity of primary human colon cancer initiating cells

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Phenotypic differentiation does not affect tumorigenicity of primary human colon cancer initiating cells

Dubash, Taronish D; Hoffmann, Christopher M; Oppel, Felix; Giessler, Klara M; Weber, Sarah; Dieter, Sebastian M; Hüllein, Jennifer; Zenz, Thorsten; Herbst, Friederike; Scholl, Claudia; Weichert, Wilko; Werft, Wiebke; Benner, Axel; Schmidt, Manfred; Schneider, Martin; Glimm, Hanno; Ball, Claudia R

Cancer letters, 2016-Feb-28, Volume: 371, Issue: 2

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Highlights • Phenotypic differentiation in vitro does not affect tumorigenicity of spheroids. • CRC TIC propagation is feasible in conditions favoring phenotypic differentiation. • Phenotypic plasticity of primary CRC TIC enriched in spheroids.

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