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Lu, Yingchang; Gustafsson, Stefan; Cousminer, Diana L; Drong, Alexander W; Evans, David M; Falchi, Mario; Li, Rui; Lu, Chen; Mägi, Reedik; Perry, John R B; Pers, Tune H; Sanna, Marianna; Shungin, Dmitry; Teumer, Alexander; Vinkhuyzen, Anna A E; Zhu, Zhihong; Bonnefond, Amélie; Borodulin, Katja; Buchman, Aron S; Cederholm, Tommy; Choi, Hyung Jin; De Jager, Philip L; Dhonukshe-Rutten, Rosalie A M; Eury, Elodie; Fumeron, Frédéric; Gärtner, Simone; Han, Bok-Ghee; Hayward, Caroline; Hillege, Hans; Kent, Jack W; Liu, Tian; Lobbens, Stéphane; Michaëlsson, Karl; Nalls, Mike A; Nielson, Carrie M; Oozageer, Laticia; Pascoe, Laura; Polašek, Ozren; Ripatti, Samuli; Swart, Karin M A; Tikkanen, Emmi; van Schoor, Natasja M; Verweij, Niek; Wright, Alan F; Forrester, Terrence; Grarup, Niels; Kristiansson, Kati; Kuulasmaa, Teemu; Scott, Robert A; Wagner, Peter J; O'Connell, Jeffrey R; Oostra, Ben A; Shuldiner, Alan R; Song, Kijoung; Vandenput, Liesbeth; Vollenweider, Peter; Boettcher, Yvonne; Kivimaki, Mika; Linneberg, Allan; Luke, Amy; Mckenzie, Colin A; Palotie, Aarno; Wareham, Nicholas J; Bennett, David A; Bertram, Lars; Blüher, Matthias; Cummings, Steven R; Czerwinski, Stefan A; Eckardt, Rahel; Hansen, Torben; Harris, Tamara B; Hastie, Nicholas; Jordan, Joanne M; Kajantie, Eero; Lehtimäki, Terho; Liu, Yongmei; Osmond, Clive; Perola, Markus; Rice, Treva K; Rivadeneira, Fernando; Sørensen, Thorkild I A; Tönjes, Anke; Tremblay, Angelo; Vitart, Veronique; Völzke, Henry; Walker, Mark; Bishop, D Timothy; Chambers, John C; Fox, Caroline; Franke, Lude; Hunter, David J; Kaplan, Robert C; Kooner, Jaspal S; Morris, Andrew P; North, Kari E; Ohlsson, Claes; Spector, Tim D; Mohlke, Karen L; Lindgren, Cecilia; Kilpeläinen, Tuomas Oskari
Nature communications, 02/2016, Volume: 7, Issue: 1Journal Article
To increase our understanding of the genetic basis of adiposity and its links to cardiometabolic disease risk, we conducted a genome-wide association meta-analysis of body fat percentage (BF%) in up to 100,716 individuals. Twelve loci reached genome-wide significance (P<5 × 10(-8)), of which eight were previously associated with increased overall adiposity (BMI, BF%) and four (in or near COBLL1/GRB14, IGF2BP1, PLA2G6, CRTC1) were novel associations with BF%. Seven loci showed a larger effect on BF% than on BMI, suggestive of a primary association with adiposity, while five loci showed larger effects on BMI than on BF%, suggesting association with both fat and lean mass. In particular, the loci more strongly associated with BF% showed distinct cross-phenotype association signatures with a range of cardiometabolic traits revealing new insights in the link between adiposity and disease risk.
