•ZnFe2O4@SiO2@L-Lisin@Cr-EDTA-MOF has been introduced as a porous organic-inorganic hybrid.•ZnFe2O4@SiO2@L-Lisin@Cr-EDTA-MOF has been employed as a catalyst for the production of sulfoxides.•ZnFe2O4@SiO2@L-Lisin@Cr-EDTA-MOF can be recovered and reused without metal leaching or decreasing its catalytic activity. In this research, the design, and synthesis of ZnFe2O4@SiO2@L-Lisin@Cr-EDTA coordination polymer magnetic nanoparticles as a novel, recyclable, and heterogeneous catalyst was developed. EDTA with four carboxylic groups as an outstanding chelating agent was utilized for the preparation of the Cr-EDTA metal-organic framework (Cr-EDTA coordination polymer). In the next step, by immobilizing the synthesized Cr-EDTA coordination polymer on the surface of the Zinc ferrite nanoparticles, ZnFe2O4@SiO2@L-Lisin@Cr-EDTA coordination polymer was synthesized. The magnetic nanocatalyst (ZnFe2O4@SiO2@L-Lisin@Cr-EDTA coordination polymer) was characterized by using various methods such as BET, FTIR, SEM, XRD, EDX, TGA, VSM, and Map analysis. Also, the oxidation of sulfides to sulfoxide was efficiently performed using the ZnFe2O4@SiO2@L-Lisin@Cr-EDTA coordination polymer catalytic system. The synthesized catalyst can be reused for five periods without loss of catalytic activity.