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Recent studies on terpenoids in Aspergillus fungi: Chemical diversity, biosynthesis, and bioactivityZhao, Wen-Yu; Yi, Jing; Chang, Yi-Bo; Sun, Cheng-Peng; Ma, Xiao-Chi
Phytochemistry (Oxford), January 2022, 2022-Jan, 2022-01-00, 20220101, Volume: 193Journal Article
Metabolites from fungi are a major source of natural small molecule drugs in addition to plants, while fungal derived terpenoids have been confirmed to have great potentials in many diseases. Aspergillus fungi are distributed in every corner of the earth, and their terpenoid metabolites exhibit promising diversity in term of both their chemistry and bioactivity. This review attempted to provide timely and comprehensive coverage of chemical, biosynthesis, and biological studies on terpenoids discovered from the genus Aspergillus, including mono-, sesqui-, di-, sester-, tri-, and meroterpenoids, in the last decade. The structural characteristics, biosynthesis, and pharmacological activities of 288 terpenoids were introduced. Display omitted •288 terpenoids were discovered from the genus Aspergillus in the recent decade.•Mono-, sesqui-, di-, sester-, tri, and mero-terpenoids were included.•The biosynthesis of diverse terpenoids in Aspergillus was introduced.•Terpenoid metabolites from Aspergillus show various bioactivities with potential.
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