The aim of the present study was to investigate the absolute luminescence efficiency of gadolinium oxysulfide powder scintillators, doped with praseodymium, cerium and fluorine (Gd2O2S:Pr,Ce,F). Gd2O2S:Pr,Ce,F is a non-hygroscopic material, emitting green light with short decay time. For the purposes of this study, two scintillating screens with coating thicknesses 35.7 and 71.2 mg/cm2, were prepared in our laboratory from Gd2O2S:Pr,Ce,F powder (Phosphor Technology, Ltd) by sedimentation on silica substrates. The light emitted by the phosphors under investigation was evaluated by performing measurements of the absolute efficiency under X-ray exposure conditions with tube voltages ranging from 50 to 130 kV. Results were compared with previously published data for Gd2O2S:Eu screens. The spectral compatibility of Gd2O2S:Pr,Ce,F with various existing optical detectors, was investigated after emission spectra measurements. Particle size and morphology parameters of the Gd2O2S:Pr,Ce,F powder phosphor were verified via scanning electron microscope (SEM) micrographs. Absolute efficiency was found to maximize at 60 kVp for the 71.2 mg/cm2 and at 90 kVp for the 35.7 mg/cm2 Gd2O2S:Pr,Ce,F screens. Absolute efficiency of the 71.2 mg/cm2 Gd2O2S:Pr,Ce,F screen was higher in the whole X-ray tube voltage range showing potential interest for non-CT medical imaging (i.e. dental radiology) or industrial digital radiography. •Two Gd2O2S:Pr,Ce,F screens (35.7 & 71.2 mg/cm2) were prepared by sedimentation.•Peak absolute efficiency was obtained for the 71.2 mg/cm2 screen at 60 kVp.•Gd2O2S:Pr,Ce,F showed very good spectral compatibility with CMOS and CCD sensors.