Several studies have investigated projectification and its effects at the firm level, but the macroeconomic implications of project work have scarcely been considered. This paper analyzes the macroeconomic effects of firm-level projectification. We study the interlinkages between different sectors by extending standard input-output modeling and analyze the static and dynamic effects of projectification. The results indicate that projectification can have positive macroeconomic implications for production/innovativeness, employment and income that differ across economic sectors, but projectification can also have negative impacts. As a major implication, the use of temporary forms of organizing cannot be recommended without reproach but depends on the economic sector and sectoral interdependencies. •Input-output analysis to study macroeconomic effects of firm-level projectification•Effects of projectification on production/innovativeness, employment and income•Differentiation between short-term (static) and long-term (dynamic) effects•Projectification has mostly positive macroeconomic implications•In some sectors projectification has negative effects (mainly short-term)