EGF promotes mammalian cell growth by suppressing cellular senescence

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EGF promotes mammalian cell growth by suppressing cellular senescence

Alexander, Peter B; Yuan, Lifeng; Yang, Pengyuan; Sun, Tao; Chen, Rui; Xiang, Handan; Chen, Jiekai; Wu, Haoyu; Radiloff, Daniel R; Wang, Xiao-Fan

Cell research, 01/2015, Volume: 25, Issue: 1

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Dear Editor, Cellular senescence is a state of irreversible proliferative arrest that is believed to be an important determinant of both cancer development and organismal aging 1. Although numerous molecules have been found to promote senescence, little is known about the nature of anti-senescent factors under physiological conditions.

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