E-resources
Peer reviewed
Open access
-
Pappas, Charalampos G.; Sasselli, Ivan R.; Ulijn, Rein V.
Angewandte Chemie, July 6, 2015, Volume: 54, Issue: 28Journal Article
Structural adaption in living systems is achieved by competing catalytic pathways that drive assembly and disassembly of molecular components under the influence of chemical fuels. We report on a simple mimic of such a system that displays transient, sequence‐dependent formation of supramolecular nanostructures based on biocatalytic formation and hydrolysis of self‐assembling tripeptides. The systems are catalyzed by α‐chymotrypsin and driven by hydrolysis of dipeptide aspartyl‐phenylalanine‐methyl ester (the sweetener aspartame, DF‐OMe). We observed switch‐like pathway selection, with the kinetics and consequent lifetime of transient nanostructures controlled by the peptide sequence. In direct competition, kinetic (rather than thermodynamic) component selection is observed. Off the beaten track: Sequence‐dependent kinetic pathway selection in chemically fueled catalytic self‐assembly of tripeptides is demonstrated, in which the control of the lifetime of the nanostructures is dictated by chemical design. Mimicking the unique features of these systems may open up opportunities to create supramolecular systems for non‐equilibrium motility and shape control.
![loading ... loading ...](themes/default/img/ajax-loading.gif)
Shelf entry
Permalink
- URL:
Impact factor
Access to the JCR database is permitted only to users from Slovenia. Your current IP address is not on the list of IP addresses with access permission, and authentication with the relevant AAI accout is required.
Year | Impact factor | Edition | Category | Classification | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Select the library membership card:
If the library membership card is not in the list,
add a new one.
DRS, in which the journal is indexed
Database name | Field | Year |
---|
Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
---|
Source: Personal bibliographies
and: SICRIS
The material is available in full text. If you wish to order the material anyway, click the Continue button.