E-resources
Peer reviewed
Open access
-
Wang, Zijun; Zhou, Pengcheng; Muecksch, Frauke; Cho, Alice; Ben Tanfous, Tarek; Canis, Marie; Witte, Leander; Johnson, Brianna; Raspe, Raphael; Schmidt, Fabian; Bednarski, Eva; Da Silva, Justin; Ramos, Victor; Zong, Shuai; Turroja, Martina; Millard, Katrina G; Yao, Kai-Hui; Shimeliovich, Irina; Dizon, Juan; Kaczynska, Anna; Jankovic, Mila; Gazumyan, Anna; Oliveira, Thiago Y; Caskey, Marina; Gaebler, Christian; Bieniasz, Paul D; Hatziioannou, Theodora; Nussenzweig, Michel C
The Journal of experimental medicine, 12/2022, Volume: 219, Issue: 12Journal Article
Individuals who receive a third mRNA vaccine dose show enhanced protection against severe COVID-19, but little is known about the impact of breakthrough infections on memory responses. Here, we examine the memory antibodies that develop after a third or fourth antigenic exposure by Delta or Omicron BA.1 infection, respectively. A third exposure to antigen by Delta breakthrough increases the number of memory B cells that produce antibodies with comparable potency and breadth to a third mRNA vaccine dose. A fourth antigenic exposure with Omicron BA.1 infection increased variant-specific plasma antibody and memory B cell responses. However, the fourth exposure did not increase the overall frequency of memory B cells or their general potency or breadth compared to a third mRNA vaccine dose. In conclusion, a third antigenic exposure by Delta infection elicits strain-specific memory responses and increases in the overall potency and breadth of the memory B cells. In contrast, the effects of a fourth antigenic exposure with Omicron BA.1 are limited to increased strain-specific memory with little effect on the potency or breadth of memory B cell antibodies. The results suggest that the effect of strain-specific boosting on memory B cell compartment may be limited.
Author
Shelf entry
Permalink
- URL:
Impact factor
Access to the JCR database is permitted only to users from Slovenia. Your current IP address is not on the list of IP addresses with access permission, and authentication with the relevant AAI accout is required.
Year | Impact factor | Edition | Category | Classification | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Select the library membership card:
If the library membership card is not in the list,
add a new one.
DRS, in which the journal is indexed
Database name | Field | Year |
---|
Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
---|
Source: Personal bibliographies
and: SICRIS
The material is available in full text. If you wish to order the material anyway, click the Continue button.