E-resources
-
Forghieri, Fabio; Nasillo, Vincenzo; Paolini, Ambra; Bettelli, Francesca; Pioli, Valeria; Giusti, Davide; Gilioli, Andrea; Colasante, Corrado; Acquaviva, Gloria; Riva, Giovanni; Barozzi, Patrizia; Maffei, Rossana; Potenza, Leonardo; Marasca, Roberto; Fozza, Claudio; Tagliafico, Enrico; Trenti, Tommaso; Comoli, Patrizia; Longo, Giuseppe; Luppi, Mario
International journal of molecular sciences, 11/2020, Volume: 21, Issue: 23Journal Article
Nucleophosmin ( ) gene mutations rarely occur in non-acute myeloid neoplasms (MNs) with <20% blasts. Among nearly 10,000 patients investigated so far, molecular analyses documented mutations in around 2% of myelodysplastic syndrome (MDS) cases, mainly belonging to MDS with excess of blasts, and 3% of myelodysplastic/myeloproliferative neoplasm (MDS/MPN) cases, prevalently classified as chronic myelomonocytic leukemia. These uncommon malignancies are associated with an aggressive clinical course, relatively rapid progression to overt acute myeloid leukemia (AML) and poor survival outcomes, raising controversies on their classification as distinct clinico-pathologic entities. Furthermore, fit patients with -mutated MNs with <20% blasts could benefit most from upfront intensive chemotherapy for AML rather than from moderate intensity MDS-directed therapies, although no firm conclusion can currently be drawn on best therapeutic approaches, due to the limited available data, obtained from small and mainly retrospective series. Caution is also suggested in definitely diagnosing -mutated MNs with blast count <20%, since -mutated AML cases frequently present dysplastic features and multilineage bone marrow cells showing abnormal cytoplasmic NPM1 protein delocalization by immunohistochemical staining, therefore belonging to -mutated clone regardless of blast morphology. Further prospective studies are warranted to definitely assess whether mutations may become sufficient to diagnose AML, irrespective of blast percentage.
Author
![loading ... loading ...](themes/default/img/ajax-loading.gif)
Shelf entry
Permalink
- URL:
Impact factor
Access to the JCR database is permitted only to users from Slovenia. Your current IP address is not on the list of IP addresses with access permission, and authentication with the relevant AAI accout is required.
Year | Impact factor | Edition | Category | Classification | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Select the library membership card:
If the library membership card is not in the list,
add a new one.
DRS, in which the journal is indexed
Database name | Field | Year |
---|
Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
---|
Source: Personal bibliographies
and: SICRIS
The material is available in full text. If you wish to order the material anyway, click the Continue button.