E-resources
Peer reviewed
-
Xia, Feng‐Wei; Guo, Bing‐Wei; Zhao, Yu; Wang, Jia‐Li; Chen, Yuan; Pan, Xiu; Li, Xin; Song, Jia‐Xing; Wan, Yu; Feng, Shun; Wu, Ming‐Yu
Advanced materials (Weinheim), 12/2023, Volume: 35, Issue: 52Journal Article
Stubborn biofilm infections pose serious threats to human health due to the persistence, recurrence, and dramatically magnified antibiotic resistance. Photodynamic therapy has emerged as a promising approach to combat biofilm. Nevertheless, how to inhibit the bacterial signal transduction system and the efflux pump to conquer biofilm recurrence and resistance remains a challenging and unaddressed issue. Herein, a boric acid‐functionalized lipophilic cationic type I photosensitizer, ACR‐DMP, is developed, which efficiently generates •OH to overcome the hypoxic microenvironment and photodynamically eradicates methicillin‐resistant Staphylococcus aureus (MRSA) and biofilms. Furthermore, it not only alters membrane potential homeostasis and osmotic pressure balance due to its strong binding ability with plasma membrane but also inhibits quorum sensing and the two‐component system, reduces virulence factors, and regulates the activity of the drug efflux pump attributed to the glycan‐targeting ability, helping to prevent biofilm recurrence and conquer biofilm resistance. In vivo, ACR‐DMP successfully obliterates MRSA biofilms attached to implanted medical catheters, alleviates inflammation, and promotes vascularization, thereby combating infections and accelerating wound healing. This work not only provides an efficient strategy to combat stubborn biofilm infections and bacterial multidrug resistance but also offers systematic guidance for the rational design of next‐generation advanced antimicrobial materials. A glycan‐targeting type I photosensitizer is developed to fight against stubborn biofilms. ACR‐DMP has high extracellular polymer penetrability and overcomes the hypoxic microenvironment, which therefore efficiently eradicates biofilm in vitro and in vivo. It not only changes the membrane potential homeostasis and the osmotic pressure balance, but also inhibits quorum sensing, two‐component system, and efflux pump to conquer biofilm resistance.
Author
![loading ... loading ...](themes/default/img/ajax-loading.gif)
Shelf entry
Permalink
- URL:
Impact factor
Access to the JCR database is permitted only to users from Slovenia. Your current IP address is not on the list of IP addresses with access permission, and authentication with the relevant AAI accout is required.
Year | Impact factor | Edition | Category | Classification | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Select the library membership card:
If the library membership card is not in the list,
add a new one.
DRS, in which the journal is indexed
Database name | Field | Year |
---|
Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
---|
Source: Personal bibliographies
and: SICRIS
The material is available in full text. If you wish to order the material anyway, click the Continue button.