New perspectives on the pathophysiology of Parkinson’s disease as assessed by saccade performance: A clinical review

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New perspectives on the pathophysiology of Parkinson’s disease as assessed by saccade performance: A clinical review

Terao, Yasuo; Fukuda, Hideki; Ugawa, Yoshikazu; Hikosaka, Okihide

Clinical neurophysiology, 08/2013, Volume: 124, Issue: 8

Journal Article

Highlights ► We review the pathophysiology of basal ganglia (BG) dysfunction in Parkinson’s disease (PD) based on saccade performance. ► Saccade abnormalities in PD may be caused by the excessive inhibition of the superior colliculus (SC) due to the increased BG output and decreased activity of the frontal cortex-BG circuit, as well as impaired suppression of reflexive saccades that may be explained by the “leaky” suppression of the SC. ► Treatment of PD, such as L-dopa therapy and deep brain stimulation, works by normalizing these abnormal BG functions, but in different ways.

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Terao, Yasuo | Fukuda, Hideki | Ugawa, Yoshikazu | Hikosaka, Okihide

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