Hepatic stellate cells activated by acidic tumor microenvironment promote the metastasis of hepatocellular carcinoma via osteopontin

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Hepatic stellate cells activated by acidic tumor microenvironment promote the metastasis of hepatocellular carcinoma via osteopontin

Song, Jin; Ge, Zhouhong; Yang, Xinrong; Luo, Qin; Wang, Cun; You, Haiyan; Ge, Tianxiang; Deng, Yun; Lin, Hechun; Cui, Yongqi; Chu, Wei; Yao, Ming; Zhang, Zhigang; Gu, Jianren; Fan, Jia; Qin, Wenxin

Cancer letters, 01/2015, Volume: 356, Issue: 2

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Highlights • Tumor acidification aggravates the activation of HCC-infiltrating HSCs. • The activation of HSCs under acidity is dependent on the phosphorylation of ERK. • Acidity-activated HSCs contribute to the metastasis of HCC. • Elevated secreted OPN of acidity-activated HSCs promotes the metastasis of HCC. • OPN shows prognosis significance, combination with HSCs activation marker α-SMA. • Acidic tumor microenvironment represents a novel mechanism for HCC metastasis and provides a potential therapeutic strategy.

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