E-resources
-
Lam, Jennifer O.; Bream, Jay H.; Sugar, Elizabeth A.; Coles, Christian L.; Weber, Kathleen M.; Burk, Robert D.; Wiley, Dorothy J.; Cranston, Ross D.; Reddy, Susheel; Margolick, Joseph B.; Strickler, Howard D.; Wentz, Alicia; Jacobson, Lisa; Guo, Yingshi; Xiao, Weihong; Gillison, Maura L.; D’Souza, Gypsyamber
Cytokine (Philadelphia, Pa.), 07/2016, Volume: 83Journal Article
•Higher serum TNF-α concentration was associated with reduced oral HPV clearance.•The association of TNF-α with oral HPV clearance was stronger among men than women.•Results are consistent with studies of TNF-α and decreased cervical HPV clearance. Initial studies suggest higher serum levels of some pro-inflammatory cytokines may be associated with decreased cervical human papillomavirus (HPV) clearance. However, the relationship of cytokines with oral HPV clearance has not been explored. From 2010 to 2014, oral rinse and serum samples were collected semi-annually from 1601 adults. Oral rinse samples were tested for HPV DNA using PCR. Based on oral HPV results, 931 serum samples were selected for cytokine evaluation to include a roughly equal number of prevalent (n=307), incident (n=313), and no oral HPV infections (n=311). Electrochemiluminescence multiplex assays were used to determine the concentrations of IL-6, IL-8, TNF-α, IFN-γ, IL-1β, IL-2, IL-4, IL-10, IL-12 and IL-13. The relationship between serum cytokine concentrations (categorized into quartiles) and oral HPV clearance was evaluated with Wei-Lin-Weissfeld regression models, adjusting for HPV infection type (prevalent vs. incident), age, HIV status, and CD4 T cell count. Higher TNF-α concentration was associated with decreased clearance in men (highest vs. lowest quartile, adjusted hazard ratio aHR=0.52, 95% CI=0.34–0.79) and women (aHR=0.76, 95% confidence interval CI=0.55–1.04), with stronger associations in men than women (p-interaction=0.049). Higher IL-2 concentration was associated with reduced clearance in men (aHR=0.69, 95% CI=0.50–0.95), but not women (p-interaction=0.058). Results were similar within CD4 T cell strata (CD4⩾500 or CD4<500 cells/μl) among HIV-infected participants. No other cytokines were associated with clearance. High serum TNF-α is associated with reduced clearance of oral HPV infection.
Author
Shelf entry
Permalink
- URL:
Impact factor
Access to the JCR database is permitted only to users from Slovenia. Your current IP address is not on the list of IP addresses with access permission, and authentication with the relevant AAI accout is required.
Year | Impact factor | Edition | Category | Classification | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Select the library membership card:
If the library membership card is not in the list,
add a new one.
DRS, in which the journal is indexed
Database name | Field | Year |
---|
Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
---|
Source: Personal bibliographies
and: SICRIS
The material is available in full text. If you wish to order the material anyway, click the Continue button.