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Galicia-Carmona, Tatiana; Arango-Bravo, Eder; Serrano-Olvera, Juan a; Flores-de La Torre, Celia; Cruz-Esquivel, Ivan; Villalobos-Valencia, Ricardo; Morán-Mendoza, Andrés; Castro-Eguiluz, Denisse; Cetina-Pérez, Lucely
Human vaccines & immunotherapeutics, 08/2021, Volume: 17, Issue: 8Journal Article
Human papillomavirus (HPV) infection is a well-known cause of cervical cancer. Therapeutic cancer vaccines are part of the current therapeutic options for HPV-associated cancers. Axalimogen filolisbac (ADXS11-001) is an immunotherapy based on live attenuated Listeria monocytogenes-listeriolysin O (Lm-LLO), designed by biological engineering to secrete an antigen-adjuvant fusion protein, composed of a truncated fragment of LLO fused to HPV. The proposed mechanism of action is that Lm-based vectors infect antigen-presenting cells (APC) and secrete HPV-LLO fusion proteins within the APC cytoplasm, these proteins are processed and presented to cytotoxic T lymphocytes (CTL), thus generating a new population of CTLs specific to HPV antigens. These HPV-specific CTLs destroy HPV infected cells. ADXS11-001 has demonstrated safety results in phase I-II studies in women with cervical cancer and is being assessed in clinical trials in patients with HPV-positive anal canal and head and neck cancers.
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