Re-evaluation of the river history, palaeosurface levels and exhumation history in northern Switzerland for the last 10 million years reveals that distinct morphotectonic events about 4.2 and 2.8 million years ago (Ma) caused major reorganisation of river networks and morphosculpture. As a result of the earlier formation of the Swiss Jura, potential relief energy in the piggy-back North Alpine Foreland Basin (NAFB) of northern central Switzerland south of the Jura fold belt was built up after 11–10 Ma. It was suddenly released by river capture at about 4.2 Ma when the Aare-Danube was captured by a tributary of the Rhône-Doubs river system which rooted southeast of the Black forest. This event triggered rapid denudation of weakly consolidated Molasse sediments, in the order of about 1 km, as constrained by apatite fission track data from drillholes in the NAFB. Likely mechanisms of river capture are (a) headward erosion of Rhône-Doubs tributaries, (b) uplift and rapidly increasing erosion of the Swiss Alps after about 5.3 Ma, and (c) gravel aggradation at the eastern termination of the Jura fold belt in the course of eastward and northward tilt of the piggy-back NAFB. A morphotectonic event between 4.2 and 2.5 Ma, probably at about 2.8 Ma, caused a phase of planation, accompanied by local gravel aggradation and temporary storage of Alpine debris. Between 2.8 and 2.5 Ma, the Aare-Rhône river system is cannibalised by the modern Rhine River, the latter later connecting with the Alpine Rhine River.