The exploration of activated alkyne-based polymerizations recently has attracted considerable attention for their huge potentials in a diverse range of real-life applications from polymer chemistry to materials science, supramolecular science, and biomedicine and pharmaceutical chemistry. In this review, we summarized the recent achievements in activated alkyne-related polymerizations and the properties and applications of the prepared polymers. Through representative examples, we elucidated the essential construction principle, developing strategy and optimization approach of each polymerization and illustrated the diverse and appealing properties and applications of the resulting polymers to offer guidance for the development of new polymerization and promote the development of polymeric materials with more superior and innovative properties and applications. Display omitted