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DUNLOP, Malcolm G; DOBBINS, Sara E; DOMINGO, Enric; SMILLIE, Claire; HENRION, Marc; FRAMPTON, Matthew; MARTIN, Lynn; GRIMES, Graeme; GORMAN, Maggie; SEMPLE, Colin; MA, Yusanne P; BARCLAY, Ella; FARRINGTON, Susan Mary; PRENDERGAST, James; CAZIER, Jean-Baptiste; OLVER, Bianca; PENEGAR, Steven; LUBBE, Steven; CHANDER, Ian; CARVAJAL-CARMONA, Luis G; BALLEREAU, Stephane; LLOYD, Amy; VIJAYAKRISHNAN, Jayaram; JONES, Angela M; ZGAGA, Lina; RUDAN, Igor; THEODORATOU, Evropi; CONSORTIUM; STARR, John M; DEARY, Ian; KIRAC, Iva; KOVACEVIC, Dujo; AALTONEN, Lauri A; RENKONEN-SINISALO, Laura; PALLES, Claire; MECKLIN, Jukka-Pekka; MATSUDA, Koichi; NAKAMURA, Yusuke; OKADA, Yukinori; GALLINGER, Steven; DUGGAN, David J; CONTI, David; NEWCOMB, Polly; HOPPER, John; JENKINS, Mark A; WHIFFM, Nicola; SCHUMACHER, Fredrick; CASEY, Graham; EASTON, Douglas; SHAH, Mitul; PHAROAH, Paul; LINDBLOM, Annika; TAO LIU; SMITH, Christopher G; TENESA, Albert; SPAIN, Sarah; BRODERICK, Peter; OOI, Li-Yin
Nature genetics, 07/2012, Volume: 44, Issue: 7Journal Article
We performed a meta-analysis of five genome-wide association studies to identify common variants influencing colorectal cancer (CRC) risk comprising 8,682 cases and 9,649 controls. Replication analysis was performed in case-control sets totaling 21,096 cases and 19,555 controls. We identified three new CRC risk loci at 6p21 (rs1321311, near CDKN1A; P = 1.14 × 10(-10)), 11q13.4 (rs3824999, intronic to POLD3; P = 3.65 × 10(-10)) and Xp22.2 (rs5934683, near SHROOM2; P = 7.30 × 10(-10)) This brings the number of independent loci associated with CRC risk to 20 and provides further insight into the genetic architecture of inherited susceptibility to CRC.
