•Evaluating methods to derive stand descriptions from large-scale sampling data.•Multi-scale approach to improve initialisation of dynamic forest models.•Simultaneous parameter prediction method best to predict tree diameter distributions.•Random Forest approach best to predict tree species composition. Most strategic and operational forest management decisions are taken based on stand-level information, and quantitative models of forest dynamics are key for developing sustainable management strategies. However, data on forest stands for the initialisation of such models that are representative at large spatial scales, e.g., countries or ecoregions, are often lacking. National Forest Inventories (NFIs) provide forest data from small sample plots at large spatial scales, yet deriving full stand information based on such data is challenging. Here, we evaluate seven methods of varying complexity for deriving quantitative stand descriptions based on sample data as provided by the Swiss NFI. We selected 271 extensively measured Swiss forests stands with unimodal diameter distributions, classified them as beech- vs. spruce-dominated in five development stages and randomly placed a small sized sample plot in each stand using the Swiss NFI sampling design (i.e., a circular plot of 500 m2). Seven modelling approaches were used to derive diameter distributions and species-specific stem numbers (i.e., tree species composition) from the sample data that are representative for a particular stand (local scale) and for stand types in general (generalised scale). The prediction performance of the modelling approaches was evaluated using 100 random samples per stand to calculate prediction errors. Generalised even-aged diameter distributions were best predicted by the simultaneous parameter prediction method (PPM), i.e. a combined three-step regression approach, with on average 1.3 to 2.5 times lower prediction errors compared to the simple pooling of diameter samples. However, uneven-aged diameter distributions were best predicted by pooling. At the local scale, the simultaneous PPM performed best for data from sample plots with fewer than 17 to 19 trees across all development stages. Prediction performance of the PPMs increased for structurally and spatially diverse local stands with positively skewed diameter distributions. A Random Forest approach was most suitable for predicting species composition at both the generalised and the local scale. Our study evaluates the strengths and weaknesses of methods to model stands based on data from small sample plots. We emphasise terminological pitfalls by consequently distinguishing local accuracy and generalised representativity of the stand descriptions. We demonstrate the feasibility of deriving locally accurate stands using data from small forest sample plots and evaluate the derivation of generalised stands representative at large regions. At both scales, our developments contribute to an improved initialisation of forest models and thus to a more realistic modelling of forest development under future boundary conditions.