As Earth faces a crisis of biodiversity loss, reintroduction of imperiled species has become an important tool toward mitigating extirpation. Current habitat quality for a reintroduced species may change dramatically under future climate scenarios, undermining or supporting species conservation efforts. Models designed to understand such change must consider the niche plasticity of a species to assess the costs and benefits of reintroduction. We integrated spatially-explicit individual-based population models with a dynamic vegetation model, using combinations of global climate models and greenhouse gas scenarios to better understand potential future carrying capacity for grizzly bears in the North Cascades Ecosystem (NCE). We estimated the ecosystem could support a grizzly bear population under several climate change scenarios through the 2080s, with the amount of high quality habitat increasing across all models, scenarios, and time periods, as compared to current conditions. Projected future habitat quality remained consistent or increased slightly along the eastern portion of the ecosystem, and increased along its central and western portions, for a net increase in high quality habitat through time. At the most plausible female home range size of 280 km2, we estimated carrying capacity would increase from a baseline of 139 female bears to 241–289 female bears. Estimated changes in habitat over time could increase grizzly bear density to 20–22 bears/1000 km2 (males and females) from the previous estimate of 17 bears/1000 km2. Species with broad ecological niches (i.e., generalists), such as grizzly bears, may be especially good candidates for reintroduction efforts in some ecosystems. Our integrated model structure provides an innovative tool for advancing reintroduction initiatives while considering some long-term risks for species.