Synthesis and Antibacterial Properties of Pyrido[2, 3-b]pyrazine Derivatives

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Synthesis and Antibacterial Properties of Pyrido[2, 3-b]pyrazine Derivatives

MIYAZAWA, Tomoyuki; TAKABATAKE, Tohru; HASEGAWA, Minoru

YAKUGAKU ZASSHI, 1997, Volume: 117, Issue: 2

Journal Article

Novel pyrido2, 3-bpyrazine 1, 4-dioxide and pyrido2, 3-bpyrazine 1-oxide derivatives were synthesized from furazano4, 5-bpyridine 3-oxide and the enolic form of 1, 3-diketones or β-ketoesters catalyzed by silica gel or molecular sieves. Their antibacterial activities were evaluated. As the results of antibacterial screening tests in vitro, pyrido2, 3-bpyrazine 1, 4-dioxide derivatives revealed strong activities, but pyrido2, 3-bpyrazine 1-oxide derivatives revealed no activities.

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MIYAZAWA, Tomoyuki | TAKABATAKE, Tohru | HASEGAWA, Minoru

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