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Rubatto, Marco; Merli, Martina; Avallone, Gianluca; Agostini, Andrea; Mastorino, Luca; Caliendo, Virginia; Barcellini, Amelia; Vitolo, Viviana; Valvo, Francesca; Fierro, Maria Teresa; Ribero, Simone; Quaglino, Pietro
Oncotarget, 05/2021, Volume: 12, Issue: 11Journal Article
Xeroderma Pigmentosum (XP) is a rare genetic disorder with a poor prognosis due to high photosensitivity in affected patients. Herein, we describe the first case of the use of cemiplimab in a patient with XP, a 19-year-old girl presented with locally advanced squamous cell carcinoma of the right periorbital and nasal region. This treatment has been undertaken after a cycle of proton beam radiotherapy. Besides, it is reported a description of the few cases in the literature describing the effectiveness of immunotherapy on skin cancers in XP-patients. This case is in line with those reported, underlining how anti-PD1 monoclonal antibodies may be a promising treatment in this genodermatosis.
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