Display omitted •Exosomes isolated from bovine milk have recently received much research interest as a possible medicinal agent.•The potential applications of bovine milk-derived exosomes (BMDEs) exhibit a wide range of possibilities.•BMDEs have the potential to combat age-related disorders and facilitate the process of healthy aging by facilitating the transfer of microRNAs.•Research findings have indicated that BMDEs have the potential to enhance immune function and exhibit anti-inflammatory properties. BMDEs can facilitate the process of tissue regeneration and restoration. Bovine milk-derived exosomes (BMDEs) have emerged as a fruitful area of investigation in age-related disease therapeutics. Through the utilization of BMDEs, researchers possess the capacity to unveil novel treatments and therapeutic interventions that have the potential to enhance the quality of life for elderly individuals across the globe. Studies have provided evidence of the efficacy of BMDEs in facilitating the regenerative processes of bone and cartilage, thus establishing their potential as a viable therapeutic avenue for addressing conditions like osteoarthritis. Although BMDEs show promise as a prospective research route for tackling age-related illnesses, including Parkinson's disease, osteoporosis, and skin rejuvenation, other unanswered questions still demand more exploration. Concerns have been raised regarding the safety and efficacy of BMDEs, especially regarding their human administration, and researchers must carefully examine these concerns to identify alternatives. In conclusion, BMDEs are an area ripe for investigation into the prevention and treatment of age-related diseases.