INTRODUCTION: Chronic Kidney Disease refers to the slow, progressive deterioration of kidney functions. However, the impairment is irreversible and imperceptible up until the disease reaches one of the later stages, demanding early detection and initiation of treatment in order to ensure a good prognosis and prolonged life. In this aspect, machine learning algorithms have proven to be promising, and points towards the future of disease diagnosis. OBJECTIVES: We aim to apply different machine learning algorithms for the purpose of assessing and comparing their accuracies and other performance parameters for the detection of chronic kidney disease. METHODS: The ‘chronic kidney disease dataset’ from the machine learning repository of University of California, Irvine, has been harnessed, and eight supervised machine learning models have been developed by utilizing the python programming language for the detection of the disease. RESULTS: A comparative analysis is portrayed among eight machine learning models by evaluating different performance parameters like accuracy, precision, sensitivity, F1 score and ROC-AUC. Among the models, Random Forest displayed the highest accuracy of 99.75%. CONCLUSION: We observed that machine learning algorithms can contribute significantly to the domain of predictive analysis of chronic kidney disease, and can assist in developing a robust computer-aided diagnosis system to aid the healthcare professionals in treating the patients properly and efficiently.