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Kaikkonen, Minna U.; Spann, Nathanael J.; Heinz, Sven; Romanoski, Casey E.; Allison, Karmel A.; Stender, Joshua D.; Chun, Hyun B.; Tough, David F.; Prinjha, Rab K.; Benner, Christopher; Glass, Christopher K.
Molecular cell, 08/2013, Volume: 51, Issue: 3Journal Article
Recent studies suggest a hierarchical model in which lineage-determining factors act in a collaborative manner to select and prime cell-specific enhancers, thereby enabling signal-dependent transcription factors to bind and function in a cell-type-specific manner. Consistent with this model, TLR4 signaling primarily regulates macrophage gene expression through a pre-existing enhancer landscape. However, TLR4 signaling also induces priming of ∼3,000 enhancer-like regions de novo, enabling visualization of intermediates in enhancer selection and activation. Unexpectedly, we find that enhancer transcription precedes local mono- and dimethylation of histone H3 lysine 4 (H3K4me1/2). H3K4 methylation at de novo enhancers is primarily dependent on the histone methyltransferases Mll1, Mll2/4, and Mll3 and is significantly reduced by inhibition of RNA polymerase II elongation. Collectively, these findings suggest an essential role of enhancer transcription in H3K4me1/2 deposition at de novo enhancers that is independent of potential functions of the resulting eRNA transcripts. Display omitted •TLR4 signaling substantially remodels the macrophage enhancer landscape•Intermediates in enhancer selection and activation can be visualized•Signal-dependent enhancer transcription is linked to H3K4 methylation•Enhancer H3K4 methylation is primarily dependent on Mll1, Mll2/4, and Mll3
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