E-resources
Peer reviewed
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Moses, Katrin; Brandau, Sven
Seminars in immunology, 04/2016, Volume: 28, Issue: 2Journal Article
Highlights • Neutrophil-lymphocyte-ratio and frequency of tumor-associated neutrophils are powerful and clinically relevant prognostic biomarkers in human oncology. • Peripheral blood low-density neutrophils are expanded in cancer patients and contain myeloid-derived suppressor cells. • Translation of mechanisms observed in murine models (including N1/N2 switch) to human oncology represents a current bottle neck in the field. • Identification and functional characterization of tumor-associated neutrophils and putative myeloid-derived suppressor cells in human tissues is another bottle neck in the field.
