E-resources
-
Dubois, Charlotte; Vanden Abeele, Fabien; Lehen’kyi, V’yacheslav; Gkika, Dimitra; Guarmit, Basma; Lepage, Gilbert; Slomianny, Christian; Borowiec, Anne Sophie; Bidaux, Gabriel; Benahmed, Mohamed; Shuba, Yaroslav; Prevarskaya, Natalia
Cancer cell, 07/2014, Volume: 26, Issue: 1Journal Article
ORAI family channels have emerged as important players in malignant transformation, yet the way in which they reprogram cancer cells remains elusive. Here we show that the relative expression levels of ORAI proteins in prostate cancer are different from that in noncancerous tissue. By mimicking ORAI protein remodeling observed in primary tumors, we demonstrate in in vitro models that enhanced ORAI3 expression favors heteromerization with ORAI1 to form a novel channel. These channels support store-independent Ca2+ entry, thereby promoting cell proliferation and a smaller number of functional homomeric ORAI1-based store-operated channels, which are important in supporting susceptibility to apoptosis. Thus, our findings highlight disrupted dynamic equilibrium of channel-forming proteins as an oncogenic mechanism. Display omitted •Disrupted dynamic equilibrium of ORAI channels determines cancer cell phenotype•Microenvironment perturbations induce ORAI1/3 association and Ca2+ entry remodeling•ORAI1/3 heteromers promote proliferation by arachidonic acid-mediated Ca2+ entry•The ORAI3 oncogenic switch represents a therapeutic target in prostate cancer Dubois et al. find that overexpression of ORAI1 or ORAI3 in prostate cancer leads to remodeling of ORAI channels and formation of ORAI1/ORAI3 heteromers. The altered stoichiometry provides an oncogenic switch that promotes cancer cell proliferation and resistance to apoptosis.
![loading ... loading ...](themes/default/img/ajax-loading.gif)
Shelf entry
Permalink
- URL:
Impact factor
Access to the JCR database is permitted only to users from Slovenia. Your current IP address is not on the list of IP addresses with access permission, and authentication with the relevant AAI accout is required.
Year | Impact factor | Edition | Category | Classification | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Select the library membership card:
If the library membership card is not in the list,
add a new one.
DRS, in which the journal is indexed
Database name | Field | Year |
---|
Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
---|
Source: Personal bibliographies
and: SICRIS
The material is available in full text. If you wish to order the material anyway, click the Continue button.