E-resources
Peer reviewed
Open access
-
Enhancing the Photo and Thermal Stability of Nicotine through Crystal Engineering with Gentisic AcidAngevine, Devin J; Camacho, Kristine Joy; Rzayev, Javid; Benedict, Jason B
Molecules (Basel, Switzerland), 10/2022, Volume: 27, Issue: 20Journal Article
The use of crystal engineering to convert liquids into crystalline solids remains a powerful method for inhibiting undesired degradation pathways. When nicotine, a liquid sensitive to both light and air, is combined with the GRAS-listed compound, gentisic acid, the resulting crystalline solid, exhibits enhanced photo and thermal stability. Despite a modest ΔTm of 42.7 °C, the melting point of 155.9 °C for the nicotinium gentisate salt is the highest reported for nicotine-containing crystalline solids. An analysis of the crystal packing and thermodynamic properties provides context for the observed properties.
