Background This study aimed to analyze the change of serum uric acid (SUA) level post peritoneal dialysis (PD), and the correlation between follow‐up SUA and prognosis in patients with PD. Methods A total of 1402 patients with PD were evaluated. We graded SUA levels into four grades at baseline, 6 months, 12 months, 18 months, and 24 months post PD, and then compared all‐cause mortality and cardiovascular mortality among patients with different SUA grades at each time point. Kaplan–Meier and Cox proportional‐hazards regression models were used in the analysis. Results The SUA levels were 7.97 ± 1.79, 7.12 ± 1.48, 7.05 ± 1.33, 7.01 ± 1.30, and 6.93 ± 1.26 mg/dl at baseline, 6, 12, 18, and 24 months, respectively. There was significant difference on all‐cause mortality among patients with PD with different graded SUA levels at 6 months post PD (p = 0.010), and the all‐cause mortality was lowest in patients with the grade of 5.65 mg/dl ≤ SUA <7.13 mg/dl. Conclusion SUA level decreased after PD during follow‐up. At 6 months post PD, the grade of 5.65 mg/dl ≤ SUA <7.13 mg/dl was appropriate for better patients' survival.