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Markov, Gabriel V.; Tavares, Raquel; Dauphin-Villemant, Chantal; Demeneix, Barbara A.; Baker, Michael E.; Laudet, Vincent; Gustafsson, Jan Åke
Proceedings of the National Academy of Sciences - PNAS, 07/2009, Volume: 106, Issue: 29Journal Article
Steroid hormones regulate many physiological processes in vertebrates, nematodes, and arthropods through binding to nuclear receptors (NR), a metazoan-specif ic family of ligand-activated transcription factors. The main steps controlling the diversification of this family are now well-understood. In contrast the origin and evolution of steroid ligands remain mysterious, although this is crucial for understanding the emergence of modern endocrine systems. Using a comparative genomic approach, we analyzed complete metazoan genomes to provide a comprehensive view of the evolution of major enzymatic players implicated in steroidogenesis at the whole metazoan scale. Our analysis reveals that steroidogenesis has been independently elaborated in the 3 main bilaterian lineages, and that steroidogenic cytochrome P450 enzymes descended from those that detoxify xenobiotics.
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