Until recently, need frustration was considered to be the absence of need satisfaction, rather than a separate dimension. Whilst the absence of need satisfaction can hamper growth, experiencing need frustration can lead to malfunctioning and subsequent psychopathology. Therefore, examining these constructs separately is vital, as they produce different outcomes, with the consequences of need frustration potentially more severe. This study sought to examine predictors of need frustration using undergraduate students and individuals from the wider community ( = 510, females 404, = 24.15). Participants completed the new need satisfaction frustration scale and measures of anxiety, stress, depression, and negative and positive affect. Support for the position that need frustration is separate to Need Satisfaction and is related to psychological health problems (i.e., ill-being) was found. However, autonomy frustration was not found to be a significant predictor of ill-being. Extending previous research, this study found relationships of stress and somatic anxiety with need frustration. Further, a relationship between need frustration with anxiety and depression occurred, when these symptom dimensions were examined separately, through distinct questionnaires. Support for the construct of need frustration highlights the necessity of examining need frustration in addition to need satisfaction within future studies. Interventions specific to reducing need frustration, specifically competence and relatedness frustration within both the educational and workplace setting are outlined.