The potential of polygenic scores to improve cost and efficiency of clinical trials

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The potential of polygenic scores to improve cost and efficiency of clinical trials

Fahed, Akl C; Philippakis, Anthony A; Khera, Amit V

Nature communications, 05/2022, Volume: 13, Issue: 1

Journal Article

Polygenic scores can identify individuals with high disease risk based on inborn DNA variation. We explore their potential to enrich clinical trials by identifying individuals based on higher risk of disease (‘prognostic enrichment’), or increased probability of benefit (‘predictive enrichment’).

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Fahed, Akl C | Philippakis, Anthony A | Khera, Amit V

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