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Doherty, Aiden; Smith-Byrne, Karl; Ferreira, Teresa; Holmes, Michael V; Holmes, Chris; Pulit, Sara L; Lindgren, Cecilia M
Nature communications, 12/2018, Volume: 9, Issue: 1Journal Article
Physical activity and sleep duration are established risk factors for many diseases, but their aetiology is poorly understood, partly due to relying on self-reported evidence. Here we report a genome-wide association study (GWAS) of device-measured physical activity and sleep duration in 91,105 UK Biobank participants, finding 14 significant loci (7 novel). These loci account for 0.06% of activity and 0.39% of sleep duration variation. Genome-wide estimates of ~ 15% phenotypic variation indicate high polygenicity. Heritability is higher in women than men for overall activity (23 vs. 20%, p = 1.5 × 10 ) and sedentary behaviours (18 vs. 15%, p = 9.7 × 10 ). Heritability partitioning, enrichment and pathway analyses indicate the central nervous system plays a role in activity behaviours. Two-sample Mendelian randomisation suggests that increased activity might causally lower diastolic blood pressure (beta mmHg/SD: -0.91, SE = 0.18, p = 8.2 × 10 ), and odds of hypertension (Odds ratio/SD: 0.84, SE = 0.03, p = 4.9 × 10 ). Our results advocate the value of physical activity for reducing blood pressure.
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