E-resources
-
Takarada, Ken, MD; Sato, Masahito, MD; Goto, Masayuki, MD; Saito, Atsushi, MD; Ikeda, Yoshio, MD; Fujita, Satoru, MD; Fuse, Koichi, MD; Takahashi, Minoru, MD; Oguro, Takeo, MD; Matsushita, Hirooki, MD; Kitazawa, Hitoshi, MD; Okabe, Masaaki, MD; Abe, Hiroshi, MD; Toba, Ken, MD; Yamashina, Akira, MD, FJCC; Aizawa, Yoshifusa, MD, FJCC
Journal of cardiology, 08/2014, Volume: 64, Issue: 2Journal Article
Abstract Background Anticoagulation therapy is essential in atrial fibrillation (AF), and in Japan, less intense control is popular. Purpose To assess the efficacy and safety with a special reference to low intensity warfarin therapy. Subjects and methods In 488 out of 508 patients with non-valvular AF, prothrombin time-international normalized ratio (PT-INR) was kept at 1.6–2.59, and they were followed for 49.5 months: 2098 person-years. The mean age was 73.7 ± 9.9 years and 62% were male. The patients were divided by age: ≥70 years and <70 years, and by the intensity of warfarin therapy: PT-INR at 1.6–1.99 and at 2.0–2.59, respectively. The clinical data and event rates, ischemic stroke and major bleeding, were compared among the subgroups. Results Heart failure, previous stroke, and higher CHADS2 score were more often reported in patients ≥70 years while males were involved more often as younger patients. A total of 166 of 339 patients ≥70 years and 69 of 149 patients <70 years belonged to the low intensity group. Ischemic stroke and major bleeding occurred in 1.47%/year and 1.27%/year, respectively but there was no difference between the two age groups and between the two intensities of warfarin therapy. Time in therapeutic range was a predictor for ischemic stroke. A fall of PT-INR to <1.6 was found in 41.9% with ischemic stroke and a rise >2.61 in 40.0% with major bleeding at the time of the events. Blunt trauma and concomitant use of antiplatelets were risks for intracranial hemorrhage in the patients ≥70 years. Conclusions The event rates were similar between the low- (1.6–1.99) and high- (2.0–2.59) intensity warfarin therapy groups in aged patients: <70 years and ≥70 years. Time in therapeutic range and a transient fall or rise in PT-INR were risks for clinical events. Blunt head trauma and concomitant use of antiplatelets were risks for intracranial hemorrhage.
Author
![loading ... loading ...](themes/default/img/ajax-loading.gif)
Shelf entry
Permalink
- URL:
Impact factor
Access to the JCR database is permitted only to users from Slovenia. Your current IP address is not on the list of IP addresses with access permission, and authentication with the relevant AAI accout is required.
Year | Impact factor | Edition | Category | Classification | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Select the library membership card:
If the library membership card is not in the list,
add a new one.
DRS, in which the journal is indexed
Database name | Field | Year |
---|
Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
---|
Source: Personal bibliographies
and: SICRIS
The material is available in full text. If you wish to order the material anyway, click the Continue button.