•Insights into the impact of COVID-19 outbreak on automobile and airline supply chain is provided.•Integrated time-to-recovery and financial impact analysis, empirical survey and semi-structured interviews were used.•Localized supply sources and industry 4.0 technologies identified as significant strategies by automobile industry.•Business continuity by defining operations at the airport and flights perceived significant strategy by airline industry.•Real-time information sharing and cooperation among supply chain stakeholders is critical. There has been an increased interest among scholars to investigate supply chain resilience (SCRes) in manufacturing and service operations during emerging situations. Grounded in the SCRes theory, this study provides insights into the impact of the COVID-19 outbreak on the automobile and airline supply chain. Both the short and long-term response strategies adopted by the two supply chains are assessed, using a combination of qualitative and quantitative techniques in three distinct phases. In phase one, we use a sequential mixed-method for resilience evaluation, integrating Time-to-Recovery (TTR) and Financial Impact (FI) analysis. In phase two, we conduct an empirical survey involving 145 firms to evaluate the short-term SCRes response strategies. In the third phase, we conduct semi-structured interviews with supply chain executives both from the automobile and airline industries to understand the long-term SCRes response strategies. Our findings indicate that: (i) the automobile industry perceived that the best strategies to mitigate risks related to COVID-19, were to develop localized supply sources and use advanced industry 4.0 (I4.0) technologies. (ii) The airline industry on the other hand, perceived that the immediate need was to get ready for business continuity challenges posed by COVID-19, by defining their operations both at the airports and within the flights. (iii) Importantly, both the sectors perceived Big Data Analytics (BDA) to play a significant role by providing real-time information on various supply chain activities to overcome the challenges posed by COVID-19. (iv) Cooperation among supply chain stakeholders is perceived, as needed to overcome the challenges of the pandemic, and to accelerate the use of digital technologies.