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Opstelten, Jorrit L.; Beelen, Rob M. J.; Leenders, Max; Hoek, Gerard; Brunekreef, Bert; van Schaik, Fiona D. M.; Siersema, Peter D.; Eriksen, Kirsten T.; Raaschou-Nielsen, Ole; Tjønneland, Anne; Overvad, Kim; Boutron-Ruault, Marie-Christine; Carbonnel, Franck; de Hoogh, Kees; Key, Timothy J.; Luben, Robert; Chan, Simon S. M.; Hart, Andrew R.; Bueno-de-Mesquita, H. Bas; Oldenburg, Bas
Digestive diseases and sciences, 10/2016, Volume: 61, Issue: 10Journal Article
Background Industrialization has been linked to the etiology of inflammatory bowel disease (IBD). Aim We investigated the association between air pollution exposure and IBD. Methods The European Prospective Investigation into Cancer and Nutrition cohort was used to identify cases with Crohn’s disease (CD) ( n = 38) and ulcerative colitis (UC) ( n = 104) and controls ( n = 568) from Denmark, France, the Netherlands, and the UK, matched for center, gender, age, and date of recruitment. Air pollution data were obtained from the European Study of Cohorts for Air Pollution Effects. Residential exposure was assessed with land-use regression models for particulate matter with diameters of <10 μm (PM 10 ), <2.5 μm (PM 2.5 ), and between 2.5 and 10 μm (PM coarse ), soot (PM 2.5 absorbance ), nitrogen oxides, and two traffic indicators. Conditional logistic regression analyses were performed to calculate odds ratios (ORs) with 95 % confidence intervals (CIs). Results Although air pollution was not significantly associated with CD or UC separately, the associations were mostly similar. Individuals with IBD were less likely to have higher exposure levels of PM 2.5 and PM 10 , with ORs of 0.24 (95 % CI 0.07–0.81) per 5 μg/m 3 and 0.25 (95 % CI 0.08–0.78) per 10 μg/m 3 , respectively. There was an inverse but nonsignificant association for PM coarse . A higher nearby traffic load was positively associated with IBD OR 1.60 (95 % CI 1.04–2.46) per 4,000,000 motor vehicles × m per day. Other air pollutants were positively but not significantly associated with IBD. Conclusion Exposure to air pollution was not found to be consistently associated with IBD.
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