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Peer reviewed
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Xu, Jianghong; Hu, Yuanyuan; Liu, Xiaoqi; Gao, Anhui; Gao, Lixin; Xu, Lei; Zhou, Yubo
Pharmaceutical chemistry journal, 10/2021, Volume: 55, Issue: 7Journal Article
A series of new 3-(indol-3-yl)-4-(pyrazolo3,4-cpyridazin-3-yl)-maleimides were synthesized and evaluated for their inhibitory activity against IDH1-R132H. Most compounds exhibited significant potency to IDH1-R132H inhibition. Among these, 3-(1-(3-(1H-imidazol-1-yl)propyl)-6-bromo-1H-indol-3-yl)-4-(1-methyl-1H-pyrazolo3,4-cpyridazin-3-yl)-1H-pyrrole-2,5-dione (compound IXb), was the most promising IDH1-R132H inhibitor (IC.sub.50 = 0.031 muM) and could significantly inhibit the production of 2-HG in U87MG IDH1-R132H cells. Preliminary structure-activity relationships and molecular modeling studies are discussed based on the experimental data obtained.
