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Goto, Ryoji; Kawakami, Haruka; Horiuchi, Yurino; Chikada, Ayaka; Yasuda, Tsutomu; Suzuki, Tetsuya; Miyazato, Yusuke; Ishikane, Masahiro; Kishino, Yuya; Miyazaki, Hideki; Igari, Toru; Katano, Harutaka; Suzuki, Tadaki; Murayama, Shigeo; Arai, Noritoshi
Internal Medicine, 2022-Nov-15, Volume: 61, Issue: 22Journal Article
We herein report a case of cerebral infarct in a patient with coronavirus disease 2019 (COVID-19) infection who died of aspiration pneumonia. The postmortem examination of the brain revealed embolic infarct with negative findings on quantitative reverse transcription polymerase chain reaction (qRT-PCR) as well as immunohistochemistry to detect severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The systemic examination only revealed low copy numbers of SARS-CoV-2 in the bronchus. This is the first and so far only autopsy case of COVID-19 infection with pathologic and virologic findings of the postmortem brain in Japan.
