Background Asthma and atopic dermatitis (AD) are chronic allergic conditions, along with allergic rhinitis and food allergy and cause high morbidity and mortality both in children and adults. This study aims to evaluate the global, regional, national, and temporal trends of the burden of asthma and AD from 1990 to 2019 and analyze their associations with geographic, demographic, social, and clinical factors. Methods Using data from the Global Burden of Diseases (GBD), Injuries, and Risk Factors Study 2019, we assessed the age‐standardized prevalence, incidence, mortality, and disability‐adjusted life years (DALYs) of both asthma and AD from 1990 to 2019, stratified by geographic region, age, sex, and socio‐demographic index (SDI). DALYs were calculated as the sum of years lived with disability and years of life lost to premature mortality. Additionally, the disease burden of asthma attributable to high body mass index, occupational asthmagens, and smoking was described. Results In 2019, there were a total of 262 million 95% uncertainty interval (UI): 224–309 million cases of asthma and 171 million 95% UI: 165–178 million total cases of AD globally; age‐standardized prevalence rates were 3416 95% UI: 2899–4066 and 2277 95% UI: 2192–2369 per 100,000 population for asthma and AD, respectively, a 24.1% 95% UI: −27.2 to −20.8 decrease for asthma and a 4.3% 95% UI: 3.8–4.8 decrease for AD compared to baseline in 1990. Both asthma and AD had similar trends according to age, with age‐specific prevalence rates peaking at age 5–9 years and rising again in adulthood. The prevalence and incidence of asthma and AD were both higher for individuals with higher SDI; however, mortality and DALYs rates of individuals with asthma had a reverse trend, with higher mortality and DALYs rates in those in the lower SDI quintiles. Of the three risk factors, high body mass index contributed to the highest DALYs and deaths due to asthma, accounting for a total of 3.65 million 95% UI: 2.14–5.60 million asthma DALYs and 75,377 95% UI: 40,615–122,841 asthma deaths. Conclusions Asthma and AD continue to cause significant morbidity worldwide, having increased in total prevalence and incidence cases worldwide, but having decreased in age‐standardized prevalence rates from 1990 to 2019. Although both are more frequent at younger ages and more prevalent in high‐SDI countries, each condition has distinct temporal and regional characteristics. Understanding the temporospatial trends in the disease burden of asthma and AD could guide future policies and interventions to better manage these diseases worldwide and achieve equity in prevention, diagnosis, and treatment. Using data from the Global Burden Disease 2019 study, we assessed the total cases and age‐standardized prevalence of both asthma and atopic dermatitis in 204 countries and territories from 1990 to 2019. In 2019, there were a total of 262 million 95% uncertainty interval (UI): 224–309 million cases of asthma and 171 million 95% UI: 165–178 million cases of AD globally; age‐standardized prevalence rates were 3416 95% UI: 2899–4066 and 2277 95% UI: 2192–2369 per 100,000 population for asthma and atopic dermatitis, respectively, a 24.1% 95% UI: −27.2 to −20.8 decrease for asthma and a 4.3% 95% UI: 3.8–4.8 decrease for atopic dermatitis compared to baseline in 1990. Asthma and atopic dermatitis continue to cause significant morbidity worldwide, having increased in total prevalence and incidence cases worldwide, but having decreased in age‐standardized prevalence rates from 1990 to 2019. Abbreviations: GBD, Global Burden Disease; UI, uncertainty interval