The process of analyzing the effects of systemic symptoms on daily living will contribute to preventing systemic and oral disease. In this study, we used anonymized data from the Comprehensive Survey of Living Conditions 2016 to analyze the associations between 42 symptoms and their effects on daily living. The subjects were 8,332 individuals (4,022 men and 4,310 women) aged 40–69 years who provided valid responses to questions related to various symptoms. The analysis was conducted by carrying out (1) univariate analysis of the association between each symptom and its effects on daily living using a contingency table; (2) comparisons between the response rate order of each symptom depending on whether it affected daily living (rank difference test), and (3) binomial logistic regression analysis (multivariate analysis) with effects on daily living (model 1) and subjective health (model 2) as the target variables. Univariate analysis identified associations for 16 systemic symptoms, including “difficulty in limb movement” (odds ratio: OR 4.17), and two oral symptoms, “difficulty chewing” (OR 1.95) and “swollen or bleeding gums” (OR 1.42). A comparison of the mean rank difference of the symptom response rates for symptoms that did or did not affect daily living found that this difference was significant (p<0.001). Binomial logistic regression analysis showed that three symptoms had significant ORs, including “fracture/sprain” (OR 3.17), “difficulty in limb movement” (OR 3.00) for both analysis models. These results suggest that some symptoms are likely to have effects on daily living, and that they warrant attention in health guidance for adults and older people.