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  • Refractory leg ulcers in a patient with 48,XXYY, a rare variant of Klinefelter's syndrome
    Läuchli, Severin ; Hafner, Jürg ; Burg, Günter
    A case of a 17-year old boy with extensive ulcers on both lower legs is presented. Clinical examination showed an unusually tall stature, obesity and eunuchoid habitus. Chromosomal analysis revealed ... a karyotype of 48,XXYY, a rare variant of Klinefelter's syndrome (47,XX1ž. After treatment with moist gauze and many recurrences, rapid ulcer healing could be achieved with topicalapplication of Factor XIII. Patients with 48,XXYY seem to be particularly prone to developing extensive leg ulcers. Possible etiologies include chronic venous insufficiency and microvascular disturbances as a consequence of fibrinolytic abnormalities. Differences between Klinefelter's syndrome (47,XX1ž and 48,XXYY are discussed.
    Vir: Acta dermatovenerologica Alpina, Panonica et Adriatica. - ISSN 1318-4458 (Letn. 11, št. 4, 2002, str. 129-132)
    Vrsta gradiva - članek, sestavni del
    Leto - 2002
    Jezik - angleški
    COBISS.SI-ID - 15535065

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    Digitalna knjižnica Slovenije - dLib.si

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