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  • The expression of Bcl-2 and pro-caspase 3 in head and neck squamous cell carcinoma = Izražanje Bcl-2 in prokaspaze 3 v ploščatoceličnih karcinomih glave in vratu
    Cör, Andrej ; Pižem, Jože ; Gale, Nina
    Background. Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer and accounts for 6% of cancers worldwide. A better understandingof its biology could lead to improved ... treatment options. Generally, the goal of cancer treatment is to abolish cell proliferation and to induce necrotic or aptoptotic cell death. Apoptosis has been recognized as a key mechanism of tumour cell elimination. Different apoptotic signals converge to induce caspase cascade activation. Caspase 3 is the central executioner caspase and is necessary for effective apoptotic cell death. Bcl-2protein family regulates apoptosis. The Bcl-2 protein itself is a productof a proto-oncogene and has an antiapoptotic action. Methods. In our study, the expression of Bcl-2 and pro-caspase 3 by immunohistochemistry in 28HNSCC graded into well, moderately and poorly differentiated cancers were investigated. Results. Our results of Bcl-2 expression confirm and extend previous reports in which Bcl-2 over-expression has been recognised as an important parameter in HNSCC biological behaviour. Three of 28 tumours (11%) showed significant Bcl-2 expression. Two of them were poorly and one was moderately differentiated. Pro-caspase 3 immunoreactivity was confined mainly to the cytoplasm. Absent or low pro-caspase 3 immunoreactivity was found only in 1 of 6 well differentiated and in 1 of 10 moderately differentiated tumoursin contrast to 5 of 12 poorly differentiated tumours. In six of 12 poorly differentiated tumours procasapse 3 immunoreactivity was strongly positive. In two cases hyperplastic epithelium was strongly positive in contrast to adjacent HNSCC in the same slide which was completely negative forpro-caspase 3. Conclusions. Our results indicate downregulation of pro-caspase 3 expression, especially in poorly differentiated HNSCC. Further studies are needed to test whether this is related to HNSCC behaviour and predict treatment outcome.
    Vir: Zdravniški vestnik : glasilo Slovenskega zdravniškega društva = Slovenian medical journal = journal of Slovenian Medical Association. - ISSN 1318-0347 (Letn. 71, suppl. 3, november 2002, str. III-39 - III-43)
    Vrsta gradiva - članek, sestavni del
    Leto - 2002
    Jezik - angleški
    COBISS.SI-ID - 15696089

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