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  • The effect of internal structure of selected water-Tween 40r-Imwitor 308r-IPM microemulsions on ketoprofene release
    Podlogar, Filip ; Bešter-Rogač, Marija ; Gašperlin, Mirjana
    Microemulsions are a promising vehicle for administrating drugs. In order to lay the basis for predicting drug release under in vivo conditions, where the microemulsion composition is continuously ... varying, we have studied the releaseof ketoprofene as a model drug, from microemulsions on a dilution line containing, initially, 20 wt.% of isopropyl miristate (IPM) and 80 wt.% of thesurfactant (Tween 40r)žco-surfactant (Imwitor 308r), 1Č1 wt.% mixture. Mixture compositions corresponding to the different types and structure of microemulsion were identified by measuring density, surface tension, electric conductivity, pH and differential scanning calorimetry. Ketoprofene release was then measured for each type and structure. The main factor influencing ketoprofene release was shown to be the strength of the interactions between microemulsion components. Strong interactions prevented rapid ketoprofene release in the water-in oil region, although the release was not dependent on the degree of percolation. Release kinetics in all cases follow zero order kinetics, indicating that the release rate is dependent on the diffusion of ketoprofene inside the microemulsion carrier. Combining different methods to obtain the physical and structural properties of microemulsions can be thus used to predict the release of ketoprofen from a microemulsion.
    Vir: International journal of pharmaceutics. - ISSN 0378-5173 (Vol. 302, no. 1-2, 2005, str. 68-77)
    Vrsta gradiva - članek, sestavni del
    Leto - 2005
    Jezik - angleški
    COBISS.SI-ID - 1810801

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