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Pregled pomembnejših inhibitorjev 5[alfa]-reduktaz tipa 1 in 2 = An overview of importnant 5[alpha]-reductase type 1 and 2 inhibitorsBeranič, Nataša, 1985- ; Lanišnik-Rižner, Tea ; Gobec, Stanislav, 1970-The 5alpha-reductase (5AR) type 1 and 2 enzymes catalyze the reduction of different 4-ene-3-oxosteroids (including testosterone) into the most potent androgen, 5á-dihydrotestosterone. Increased ... activities of the 5ARs are relatedto different diseases, such as benign prostatic hyperplasia, androgen alopecia, hirsutism and acne. The 5ARs are thus emerging drug targets for treatment of 5á-dihydrotestosterone-dependent diseases. Here, we review the major classes of 5AR inhibitors. Of many 5AR inhibitors reported over the lastfour decades, the only finasteride and dutasteride are used in the therapyof benign prostatic hyperplasia, and finasteride also in the therapy ofandrogen alopecia. Due to their serious side effects and the need for more effective and selective inhibitors, the search for inhibitors continues. Over the last few years, the discovery of new non-steroidal inhibitors has gained great importance, as these compounds have fewer interactions with receptors orwith other enzymes of the steroid endocrine system.Vir: Farmacevtski vestnik : strokovno glasilo slovenske farmacije = pharmaceutical journal of Slovenia. - ISSN 0014-8229 (Letn. 63, jul. 2012, str. 168-177)Vrsta gradiva - članek, sestavni delLeto - 2012Jezik - angleškiCOBISS.SI-ID - 29980889
Avtor
Beranič, Nataša, 1985- |
Lanišnik-Rižner, Tea |
Gobec, Stanislav, 1970-
Teme
Testosterone 5-Alpha-Reductase |
Antagonists And Inhibitors |
Finasteride |
Stanolone |
Azasteroids |
Prostatic Hyperplasia |
Alopecia |
Hirsutism |
Testosteronska 5-alfa-reduktaza |
Azasteroidi |
Prostata, hiperplazija |
Finasterid |
Stanolon |
Hirzutizem |
Alopecija |
zdravila |
steroidi |
inhibitorji |
reduktaze
Vnos na polico
Trajna povezava
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Faktor vpliva
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Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
Ime baze podatkov | Področje | Leto |
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Beranič, Nataša, 1985- | 31946 |
Lanišnik-Rižner, Tea | 11699 |
Gobec, Stanislav, 1970- | 15284 |
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