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  • Solution structure of miRNA:mRNA complex
    Cevec, Mirko ; Plavec, Janez
    The use of contemporary nuclear magnetic resonance (NMR) methods in the studies of model systems between microRNA (miRNA) and messenger RNA (mRNA) is reviewed. We describe our studies on structural ... features of 33-nt RNA model construct between let-7 miRNA and lin-41 mRNA at the second binding site. let-7 miRNA inhibits translation of lin-41 gene through formation of two complexes with the target sequence within 3' untranslated reginn of lin-41 mRNA in Caenorhabditis elegans. The base pairing, asymmetric internal loops, and adenine bulge in both the complementary sites are important for regulation of gene expression.
    Vir: MicroRNAs and the immune system : methods and protocols (Str. 251-265)
    Vrsta gradiva - članek, sestavni del
    Leto - 2010
    Jezik - angleški
    COBISS.SI-ID - 4508698
    DOI

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