-
Vrednotenje proteoliznih encimov in njihovih inhibitorjev kot prognostičnih pokazateljev karcinoma dojke : magistrsko deloLevičar, NatašaProteolytic enzymes have been proposed as the new potentail biological prognostic factors for breast cancer patients. Determination of their concentrations in primary tumours may facilitate decision ... about treatment of breast cancer patients, following the removal of the tumor. Previous investigations have shown, that increased expression of cysteine proteinases cathepsins B and L (CatB and CatL) and urokinase-type plasminogen activator (uPA) in tumor, compared to normal breast tissue, were associated with breast tumour progression. Similarly, altered levels of their endogenous inhibitors stefins A and B (StA and StB) and plasminogen activator inhibitor-1 (PAI-1) were found in malignant tumours. We determined the levels of CatB, CatL, StA, StB, uPA and PAI-1 in 150 primary invasive ductal carcinoma and 83 matched control breast tissues by measuring activity and by ELISA. Proteinases and their inhibitors were found 2-12 fold increased in tumour tissue compared withthe controls. Good correlation was found between tumour levels of CatB andCatL (r=0.65). Weak correlation was found between uPA and PAI-1 (r=0.41) and very low correlation between CatB and uPA (r=0.32). Cathepsins and stefinswere not related with standard clinical and histopathological factors indicating tumour progression. In contrast, elevated levels of uPA correlated well with the histological grade (p<0.00) and with positive ER (p<0.01), whilePAI-1 correlated with all histopahological factors, except tumour size. We evaluated and compared the prognostic impact of all these biological factors. Increased levels of uPA and PAI-1 had the most significant impact on shorter disease-free survival (DFS) (p<0.00, p<0.02, respectively) and overallsurvival (OS) (p,0.00, p,0.05, respevtively). (Abstract truncated at 2000 characters.)Vrsta gradiva - magistrsko delo ; neleposlovje za odrasleZaložništvo in izdelava - Ljubljana : [N. Levičar], 1999Jezik - slovenskiCOBISS.SI-ID - 470863
Avtor
Levičar, Nataša
Drugi avtorji
Lah Turnšek, Tamara
Teme
Breast neoplasm |
Diagnosis |
Carcinoma |
Diagnosis |
Cathepsins |
Diagnostic use |
Cathepsins |
Antagonists and inhibitors |
Urokinase |
Antagonists and inhibitors |
Dojka, novotvorbe |
Diagnostika |
Karcinom |
Diagnostika |
Katepsini |
Diagnostična raba |
Katepsini |
Antagonisti in inhibitorji |
Urokinaza |
Diagnostična raba |
Urokinaza |
Antagonisti in inhibitorji |
patologija |
karcinom |
proteinaze |
inhibitorji |
prognostični dejavniki
Vnos na polico
Trajna povezava
- URL:
Faktor vpliva
Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
Ime baze podatkov | Področje | Leto |
---|
Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
---|---|
Levičar, Nataša | 17003 |
Lah Turnšek, Tamara | 07802 |
Izberite prevzemno mesto:
Prevzem gradiva po pošti
Obvestilo
Gesla v Splošnem geslovniku COBISS
Izbira mesta prevzema
Mesto prevzema | Status gradiva | Rezervacija |
---|
Prosimo, počakajte trenutek.