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COVID-19 and cholesterol biosynthesis [Elektronski vir] : towards innovative decision support systemsKočar, Eva, 1992- ...With COVID-19 becoming endemic, there is a continuing need to find biomarkers characterizing the disease and aiding in patient stratification. We studied the relation between COVID-19 and cholesterol ... biosynthesis by comparing 10 intermediates of cholesterol biosynthesis during the hospitalization of 164 patients (admission, disease deterioration, discharge) admitted to the University Medical Center of Ljubljana. The concentrations of zymosterol, 24-dehydrolathosterol, desmosterol, and zymostenol were significantly altered in COVID-19 patients. We further developed a predictive model for disease severity based on clinical parameters alone and their combination with a subset of sterols. Our machine learning models applying 8 clinical parameters predicted disease severity with excellent accuracy (AUC = 0.96), showing substantial improvement over current clinical risk scores. After including sterols, model performance remained better than COVID-GRAM. This is the first study to examine cholesterol biosynthesis during COVID-19 and shows that a subset of cholesterol-related sterols is associated with the severity of COVID-19.Vir: iScience [Elektronski vir]. - ISSN 2589-0042 (Vol. 26, iss. 10, [article no.] 107799, 2023, str. 1-16)Vrsta gradiva - e-članekLeto - 2023Jezik - angleškiCOBISS.SI-ID - 165467907
Avtor
Kočar, Eva, 1992- |
Katz, Sonja |
Pušnik, Žiga, računalničar |
Bogovič, Petra |
Turel, Gabriele |
Skubic, Cene |
Režen, Tadeja |
Strle, Franc, 1949- |
Martins dos Santos, Vitor A. P. |
Mraz, Miha |
Moškon, Miha, računalništvo |
Rozman, Damjana, 1960-
Teme
COVID-19 |
holesterol |
biosinteza |
steroli |
lipidi |
bioinformatika |
ocenjevanje v zdravstveni tehnologiji
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Baze podatkov, v katerih je revija indeksirana
Ime baze podatkov | Področje | Leto |
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Kočar, Eva, 1992- | 52386 |
Katz, Sonja | ![]() |
Pušnik, Žiga, računalničar | 52244 |
Bogovič, Petra | 27886 |
Turel, Gabriele | 50050 |
Skubic, Cene | 50455 |
Režen, Tadeja | 22459 |
Strle, Franc, 1949- | 13301 |
Martins dos Santos, Vitor A. P. | ![]() |
Mraz, Miha | 13442 |
Moškon, Miha, računalništvo | 29198 |
Rozman, Damjana, 1960- | 06013 |
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